Low bone mineral density predictor of ASCVD in women
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Evaluating bone mineral density can help predict atherosclerotic CVD events in women, according to a study published in Heart.
According to the study background, the population-adjusted risk for ASCVD mortality is greater in women than in men (21% vs. 15%), so metrics beyond traditional risk factors may be needed to predict ASCVD risk more accurately in women.
The researchers analyzed 12,681 Asian women aged 50 to 80 years. During a median follow-up of 9.2 years, 3.7% had an MI or stroke and 1.9% died of ASCVD.
According to the researchers, lower bone mineral density (BMD) at the lumbar spine, femur neck and total hip were independent risk factors for ASCVD events (adjusted HR per 1 standard deviation [SD] decrease in BMD at lumbar spine = 1.16; aHR per 1 SD decrease in BMD at femur neck = 1.29; adjusted HR per 1 SD decrease in BMD at total hip = 1.38; P < .001 for all).
In the analysis, the clinical diagnosis of osteoporosis was independently linked to higher risk for ASCVD events (aHR per 1 SD decrease in BMD = 1.79; P <.001).
Lower BMD at lumbar spine, femur neck and total hip and diagnosis of osteoporosis were all linked to higher risk for ASCVD death (P < .001 for all), according to the researchers.
Adding BMD parameters or a diagnosis of osteoporosis or osteopenia to traditional risk factors improved discrimination of ASCVD events in this population (C-index, P < .01 for all; net reclassification index, P < .01 for all; integrated discrimination improvement, P < .01 for most), the researchers wrote.
“The evaluation of BMD provides predictive value for ASCVD events in women. Moreover, it provides independent and incremental prognostic value over that for age and other clinical risk factors. Further studies are warranted to determine whether the evaluation of BMD translates into long-term clinical benefits in women,” the researchers wrote.
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