CHAMP-HF: Certain factors confer improved LVEF in HFrEF
In HF with reduced ejection fraction, factors such as HF duration, nonischemic cardiomyopathy and no coronary disease may be linked to improvements in left ventricular ejection fraction and better outcomes, researchers reported.
“This study examined changes in LVEF over time for outpatients with HFrEF enrolled in a contemporary registry,” Adam D. DeVore, MD, MHS, assistant professor of medicine at Duke University School of Medicine and member in the Duke Clinical Research Institute, and colleagues wrote. “Our data add to a growing literature on myocardial recovery and may inform patient and clinician discussions on optimal use and timing of interventions that are indicated by LVEF.”
For this assessment of outpatients with HFrEF in the CHAMP-HF registry published in Circulation: Heart Failure, researchers analyzed patients with LVEF assessments at baseline and at least 1 year of follow-up (n = 2,623; median age, 67 years; 40% with ischemic cardiomyopathy; median HF duration, 2.8 years) with the aim of identifying specific factors associated with LVEF improvement.
During a median follow-up of 16 months, researchers observed LVEF improvements of at least 5% in approximately 50% of the cohort; at least 10% in approximately 34% of the cohort; and at least 20% in 15% of the cohort.
Factors associated with at least a 5% improvement in LVEF included:
- shorter HF duration (OR = 1.21; 95% CI, 1.17-1.25);
- no implantable cardioverter defibrillator (OR = 1.46; 95% CI, 1.34-1.55);
- lower LVEF (OR = 1.15; 95% CI, 1.1-1.19);
- nonischemic cardiomyopathy (OR = 1.24; 95% CI, 1.09-1.36); and
- no coronary disease (OR = 1.2; 95% CI, 1.03-1.35).
“Common baseline cardiac characteristics identified a population that was more likely to respond over time,” the researchers wrote. “These data may inform clinical decision-making and should be the basis for future research on myocardial recovery.”
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