Genetics and the heart: Top news of 2019
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Healio and Cardiology Today compiled a list of the most-read articles on updates in genetics and CVD published in 2019.
This year, Healio readers were most interested in research that showed genetic testing may identify risk for sudden cardiac death, the role of genetic counseling in CVD, genetic testing in lipid clinics and more.
Genetic testing may identify patients at risk for sudden cardiac death
Gene sequencing was used to identify a subset of the population predisposed to sudden cardiac death by a DNA variant, according to data presented at the American Heart Association Scientific Sessions. Read more
Genetic counseling may improve outcomes in inherited CVD
Genetic counseling has been shown to play an important role in improving outcomes in patients who inherited CVD in a study previously presented at a conference held by the National Society of Genetic Counselors. Healio spoke with Brittney Murray, MS, CGC, genetic counselor in the arrhythmogenic right ventricular dysplasia/cardiomyopathy program at Johns Hopkins Hospital, about the study she and her colleagues conducted and how genetic counseling can be beneficial in this patient population. Read more
VIDEO: Updates on direct-to-consumer genetic testing for CVD
In this video exclusive, Elizabeth McNally, MD, PhD, cardiologist and director of the Center for Genetic Medicine at Northwestern University, discusses implications of straight-to-consumer genetic testing. Read more
Seven-point genetic testing may identify more patients with FH
Adding four more genes to traditional genetic testing may identify more patients with familial hypercholesterolemia, which may be especially beneficial for black patients in whom traditional scoring criteria may not be sufficient, according to data from the second-place oral poster winner presented at the National Lipid Association Scientific Sessions. Read more
Genetic testing may offer diagnostic advantage at lipid clinics
Genetic testing can be used by clinicians who treat patients at lipid clinics, especially for the diagnosis of conditions such as familial hypercholesterolemia, according to a presentation at the National Lipid Association Scientific Sessions. Read more
Genetic factor may identify patients at risk for spontaneous coronary artery dissection
The first genetic risk locus for spontaneous coronary artery dissection has been identified, according to a study published in the Journal of the American College of Cardiology. Read more
Titin variants may affect LVEF despite cardiomyopathy status
Patients of European ancestry with proportion spliced in truncating variants in the titin, or TTN, gene had an abnormal phenotype exemplified by lower left ventricular ejection fraction regardless of their cardiomyopathy status, according to a study published in Circulation. Read more
Polygenic risk scores may predict CAD
Two genome-wide polygenic risk scores were able to predict prevalent CAD in patients, according to a study published in Circulation: Genomic and Precision Medicine. Read more
Genetic variant linked to HF in people of African American or Latino ancestry
The TTR V122I genetic variant was significantly linked to HF among patients of African or Latino ancestry, according to a study published in JAMA. Read more