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FFR improvement reduces symptoms, event rates in PCI
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In a post hoc analysis of patients from the FAME 1 and FAME 2 trials, patients with greater improvement in fractional flow reserve after PCI had greater symptom improvement and lower event rates.
The researchers analyzed 639 patients with 837 lesions who had FFR measured in FAME 1 or had FFR-guided PCI plus optimal medical therapy in FAME 2.
The lesions were stratified into tertiles based on change in FFR after PCI: change of 0.18 or less, change of 0.19 to 0.31 and change of 0.32 or more.
Compared with the highest tertile of change, vessel-oriented clinical events, defined as cardiac death, revascularization and MI, occurred more often in the lowest tertile (9.1% vs. 4.7%; HR = 2.01; 95% CI, 1.03-3.92), Stephane Fournier, MD, from the department of cardiology at the Cardiovascular Center Aalst in Belgium, and colleagues wrote.
Greater change in FFR also conferred greater symptomatic relief (OR = 1.33; 95% CI, 1.02-1.74), according to the researchers.
“This study confirms and quantifies our clinical intuition, namely, that the larger the [change in] FFR, the larger the symptomatic improvement,” the researchers wrote. “These data extend the findings of the ORBITA trial, which showed a physiology-stratified effect of PCI on symptomatic relief, to a broader patient population.” – by Erik Swain
Disclosures: Fournier reports no relevant financial disclosures. Please see the study for all other authors’ relevant financial disclosures.
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