Aspirin before, after CABG reduces long-term mortality risk
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Patients who took aspirin before and after CABG had a decreased risk for long-term mortality, according to data presented at the Euroanaesthesia Congress.
“Cardiac surgery frequently provokes an extreme and complex stress and hypercoagulable state, with an increased predisposition to long-term vascular morbidity and mortality,” Jian-Zhong Sun, MD, professor of anesthesiology at Thomas Jefferson University in Philadelphia, and colleagues wrote. “Perioperative aspirin may attenuate the adverse response, provide cardiovascular protection with potential short- and long-term benefits for survival.”
Researchers analyzed data from 4,132 patients who underwent CABG. Patients were divided into four groups: those who received preoperative aspirin (76.5%), patients who did not receive preoperative aspirin (23.5%), those who received postoperative aspirin (92.3%) and those who did not receive postoperative aspirin (7.7%).
Patients who took preoperative aspirin had more comorbidities, including diabetes, smoking, angina, peripheral vascular disease, previous MI and hypertension.
Compared with patients who did not take aspirin before or after surgery, the risk for 4-year mortality was significantly reduced in those who took aspirin before (14.8% vs. 18.1%; RR = 0.82; 95% CI, 0.75-0.89) or after CABG (10.7% vs. 16.2%; RR = 0.66; 95% CI, 0.5-0.82).
“The results of the present study revealed that the treatment effect with preoperative aspirin regarding the long-term survival (15%-20% improvement) was similar to that observed in other proven medical treatments, indicating that aspirin is an effective drug in improving long-term survival of patients with CABG,” Sun and colleagues wrote in an abstract.
“We believe that all patients undergoing CABG should take aspirin before and after the procedure, except those for whom aspirin is contraindicated,” Sun said in a press release. – by Darlene Dobkowski
Reference:
Sun J, et al. Abstract 960. Presented at: Euroanaesthesia Congress; June 2-4, 2018; Copenhagen, Denmark.
Disclosures: The authors report no relevant financial disclosures.