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7 recent articles on advancement in stroke research
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The American Stroke Association is celebrating its 20th anniversary, while at the same time commemorating Stroke Awareness Month.
In a continuing effort to raise awareness for Stroke Awareness Month, Cardiology Today has compiled a list of seven recent stories on advancements in stroke research.
LAA closure during cardiac surgery lowers long-term stroke, mortality risk
Left atrial appendage closure during cardiac surgery was linked to reduced risk for subsequent stroke and all-cause mortality among patients undergoing cardiac surgery, according to data published in JAMA.
According to the study, many patients who undergo cardiac surgery have a history of atrial fibrillation, which is associated with increased risk for stroke. Performing left atrial appendage occlusion (LAAO) during surgery may reduce the long-term risk for stroke, the researchers wrote in the study background.
WAKE-UP: Alteplase effective in acute stroke with suspected recent onset
Among patients with acute stroke of unknown time of onset but MRI findings indicating onset was recent, IV thrombolysis with alteplase resulted in a better functional outcome than treatment with placebo, according to the results of the WAKE-UP trial.
The findings were presented at the European Stroke Organization Conference and published in The New England Journal of Medicine.
Recurrent stroke risk steady after TIA, minor stroke
The risk for CV events was consistent over 5 years in patients who had transient ischemic attack or minor stroke, according to a study presented at the European Stroke Organization Conference and published in The New England Journal of Medicine.
“There may be potential for reducing recurrent strokes by ongoing secondary prevention measures,” Pierre Amarenco, MD, of the department of neurology and stroke center at Bichat Hospital in Paris, and colleagues wrote.
KP-RHYTHM: Greater AF burden increases risk for ischemic stroke
Among patients with paroxysmal atrial fibrillation, greater AF burden was linked to an increased risk for ischemic stroke independent of known risk factors, according to a study published in JAMA Cardiology.
Clopidogrel, aspirin combination lowers stroke odds, raises brain bleeding risk
The combination of clopidogrel and aspirin may lower the risk for major ischemic events among patients with minor ischemic stroke or high-risk transient ischemic attack compared with aspirin alone, according to results of the POINT study.
Although this combination may lower ischemic event risk, it may raise the risk for major hemorrhagic bleeding, researchers reported at the European Stroke Organization Conference. The results were simultaneously published in The New England Journal of Medicine.
NAVIGATE ESUS: Rivaroxaban fails to reduce recurrence in embolic stroke
Rivaroxaban did not reduce the risk for recurrent stroke in patients with embolic stroke compared with aspirin, although it increased the risk for bleeding, according to data presented at the European Stroke Organization Conference.
The results were simultaneously published in The New England Journal of Medicine.
Obesity may predict stroke outcomes in black adults
Black adults with obesity have markedly higher risk for experiencing poor outcomes after an intracerebral hemorrhage vs. white adults, according to findings published in Obesity Science & Practice.
“Although race did not influence the overall study results, within the nonwhite population, obesity was associated with poor hospital discharge disposition outcome, a result that was not observed in patients with normal weight and overweight,” Ifeanyi O. Iwuchukwu, MD, an assistant professor of neuroscience at Louisiana State University, and colleagues wrote. “Interestingly, this observation was not detected in the white population group.”