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Dual-layered stents show promise in treating extracranial carotid artery stenosis
Dual-layered carotid stents may be safe and effective for the treatment of extracranial carotid artery stenosis and have a relatively low rate of procedural failure and postprocedural adverse events, according to a meta-analysis published in Catheterization and Cardiovascular Interventions.
According to a study from Anna Sannino, MD, of the division of cardiology at the University of Naples Federico II in Italy, and colleagues, procedural and postprocedural ischemic events still represent the “Achilles’ heel” of carotid artery stenting, and postprocedural ipsilateral stroke still accounts for a significant proportion of all CAS-related adverse events.
To report the clinical efficacy of dual-layered mesh-covered carotid stent systems in clinical practice, the researchers enrolled 635 patients in 10 studies and analyzed a composite endpoint of 30-day stroke and death and the occurrence of procedural failure after CAS with the use of two different double-layered carotid stent systems (CGuard, InspireMD; and RoadSaver, Terumo Europe).
According to the results of the study, at 30 days, there were very low rates of stroke and death (event rate = 0.02; 95% CI, 0.01–0.04).
Rates of procedural failure were also low with double layered stents (event rate = 0.03; 95% CI, 0.01-0.08).
A subgroup analysis showed no difference in the occurrence of death, stroke and procedural failure at 30 days between the two stent systems (P=.979).
“The present meta-analysis suggests that dual-layered carotid stents could be safely used for the treatment of extracranial carotid artery stenosis, with a quite low rate of procedural unsuccess and of postprocedural adverse events,” Sannino and colleagues wrote. “Future, adequately powered trials are needed to definitely prove the clinical utility of these stents.”– by Dave Quaile
Disclosures: The authors report no relevant financial disclosures.