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Increased BMI affects CV health in young adults

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Kaitlin H. Wade

Young adults with high BMI are more likely to have poorer CV health, according to results presented at the European Society of Human Genetics Conference.

“The results support efforts to tackle the obesity epidemic from an early age in order to prevent the development of [CV] changes known to be precursors of [CV] ill health and disease,” Kaitlin H. Wade, research associate at the Medical Research Council Integrative Epidemiology Unit at the University of Bristol in the United Kingdom, said in an interview with Cardiology Today.

Researchers used Mendelian randomization analysis, which uses genetic information to improve causal inference, to assess the causal role of BMI on CV phenotypes in participants from the Avon Longitudinal Study of Parents and Children aged 17 to 21 years. A recall-by-genotype study was also conducted using an independent sample of 418 participants from the same cohort at age 21 years.

Results from both analyses showed that participants with increased BMI have higher BP and left ventricular mass (change in LV mass index per kg/m² using Mendelian randomization: 1.09 g/m^2.7; 95% CI, 0.63-1.54). In recall-by-genotype analysis, participants had increased cardiac output (estimate per 3.55 kg/m²: 0.11 L/min/m^1.83; 95% CI, 0.03-0.19) and stroke volume (estimate per 3.55 kg/m²: 1.49 mL/m^2.04; 95% CI, 0.62-2.35). BMI did not appear to have a causal influence on heart rate in both analyses.

“Based on these findings, we have plans to further untangle this relationship by focusing on likely intermediary disease mechanisms including metabolomics, the study of the chemical processes involved in the functioning of cells,” Wade told Cardiology Today. “It will be important to replicate these findings within other cohorts that have rich data on adiposity and [CV] health alongside genetic and other ‘omic’ data.” – by Darlene Dobkowski

References:

Wade KH, et al. Abstract C10.3. Presented at: European Society of Human Genetics Conference; May 27-30, 2017; Copenhagen, Denmark.

Wade KH, et al. BioRxiv. 2017;doi:10.1101/112912.

For more information:

Kaitlin H. Wade can be reached at kaitlin.wade@bristol.ac.uk.

Disclosures: The researchers report no relevant financial disclosures.