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Non-O blood groups at increased risk for CV events

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Individuals with non-O blood groups were at an increased risk for coronary events and combined CV events, according to findings presented at Heart Failure 2017 in Paris.

“It has been suggested that people with non-O blood groups (A, B, AB) are at higher risk for [MI] and overall [CV] mortality, but this suggestion comes from case-control studies, which have a low level of evidence,” Tessa Kole, a master’s degree student at the University Medical Centre Groningen in the Netherlands, said in a press release. “If this was confirmed, it could have important implications for personalized medicine.”

Kole and colleagues conducted a meta-analysis of prospective studies with more than 1.3 million participants combined. The researchers looked at associations between blood type and all coronary events, combined CV events and fatal coronary events.

There were 23,154 CV events in total. In the analysis of coronary events, 1.5% (n = 11,437) of people with non-O blood had a coronary event vs. 1.4% (n = 7,220) of participants with O blood (OR = 1.09; 95% CI, 1.06-1.13).

For combined CV events, 2.5% (n = 17,449) of participants with non-O blood had an event vs. 2.3% (n = 10,916) of those with O blood (OR = 1.09; 95% CI, 1.06-1.11).

There was no significant association between risk for fatal coronary event and blood type (OR = 1; 95% CI, 0.85-1.18).

“More research is needed to identify the cause of the apparent increased [CV] risk in people with a non-O blood group,” Kole said in the release. “Obtaining more information about risk in each non-O blood group (A, B and AB) might provide further explanations of the causes.”

Possible mechanisms include higher concentration of von Willebrand factor and increased rates of dyslipidemia in individuals with non-O blood, Kole and colleagues wrote in an abstract. – by Cassie Homer

Reference:

Kole T, et al. Abstract 697. Presented at: Heart Failure 2017 and the 4th World Congress on Acute Heart Failure; April 29-May 2, 2017; Paris.

Disclosure: The researchers report no relevant financial disclosures.