This article is more than 5 years old. Information may no longer be current.

Ventricular septal defect, aortic valve disease lead to higher adverse maternal outcomes

Issue: April 2016

Add topic to email alerts

Receive an email when new articles are posted on

Please provide your email address to receive an email when new articles are posted on .

Subscribe

Added to email alerts

You've successfully added to your alerts. You will receive an email when new content is published.

Click Here to Manage Email Alerts

You've successfully added to your alerts. You will receive an email when new content is published.

Click Here to Manage Email Alerts

Back to Healio

We were unable to process your request. Please try again later. If you continue to have this issue please contact customerservice@slackinc.com.

Back to Healio

Women with ventricular septal defects, Eisenmenger’s syndrome or aortic valve disease are at elevated risk for adverse outcomes during or after pregnancy, according to findings presented at Cardiology 2016.

However, women with other congenital heart diseases, including pulmonary stenosis, Tetralogy of Fallot, transposition of the great arteries or Ebstein’s anomaly, were not at excess risk for pregnancy-related adverse outcomes compared with the general population, researchers found.

Angeline D. Opina, MD, clinical postdoctoral fellow in pediatric cardiology, Baylor College of Medicine, Houston, and colleagues investigated whether women with congenital heart disease were at increased risk for adverse maternal outcomes, including death, acute renal failure and cardiac arrest.

Using the Texas Inpatient Public Use Data File, they analyzed 5,378,337 pregnancy-related discharges, of which 2,747 were for women with congenital heart disease; age distribution was similar for women with and without congenital heart disease (P = .13).

Opina and colleagues found that adverse maternal outcomes were more common in women with congenital heart disease than in women without it:

• acute renal failure (0.69% vs. 0.06%; P < .001);

• cardiac arrest (0.26% vs. 0.01%; P < .001);

• ICU stay (18.33% vs. 3.66%; P < .001);

• longer median length of stay (3 days [interquartile range, 2-4] vs. 2 days [interquartile range, 2-3]; P < .001); and

• death (0.36% vs. 0.02%; P < .001).

However, results varied by lesion type. No women with pulmonary stenosis, Tetralogy of Fallot, transposition of the great arteries or Ebstein’s anomaly had peripartum death, cardiac arrest or acute renal failure, Opina and colleagues reported.

Conversely, they found, compared with women with no congenital heart disease, women with ventricular septal defect or Eisenmenger’s syndrome, which share the same ICD-9 code, were more likely to experience peripartum acute renal failure (OR = 12; 95% CI, 4-31), cardiac arrest (OR = 13; 95% CI, 2-96) or death (OR = 23; 95% CI, 6-92).

Similarly, compared with those without congenital heart disease, women with aortic valve disease were more likely to have acute renal failure (OR = 19; 95% CI, 7-50) or cardiac arrest (OR = 22; 95% CI, 3-154), according to the researchers. – by Erik Swain

Reference:

Opina AD, et al. Abstract 225. Presented at: Cardiology 2016, the 19th Annual Update on Pediatric and Congenital Cardiovascular Disease; Feb. 24-28, 2016; Orlando, Fla.

Disclosure: Cardiology Today could not obtain relevant financial disclosures.