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CV risk factors, obesity common in women undergoing hysterectomy
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In a recent study, women who underwent hysterectomy with ovarian conservation had a higher frequency of CV risk factors, particularly obesity.
The Mayo Clinic Study of Uterine Disease and Health included 3,816 women in Olmsted County, Minnesota, who underwent hysterectomy with ovarian conservation from 1965 to 2002. The median age at hysterectomy was 41 years. The goal was to identify CV risk factors and pre-existing CVD prior to the index date in women undergoing hysterectomy and matched controls who did not undergo hysterectomy prior to the index date or the date of the case hysterectomy.
Women who underwent hysterectomy had an increased likelihood of obesity (OR = 1.44; 95% CI, 1.26-1.64), metabolic syndrome (OR = 1.93; 95% CI, 1.23-3.02) and hyperlipidemia (OR = 1.41; 95% CI, 1.08-1.84) compared with controls, according to univariable analysis.
Only the association between hysterectomy and obesity persisted in multivariable analysis (OR = 1.42; 95% CI, 1.24-1.62). Analysis stratified by age indicated that this association was significant among women younger than 36 years and aged 41 to 50 years.
Hypertension also was significantly more common among women aged 36 to 40 years who underwent hysterectomy (OR = 1.92; 95% CI, 1.15-3.2), but not in any other evaluated age groups.
The researchers noted an increased risk for stroke among women younger than 36 years who underwent hysterectomy, according to univariable analysis. The risk for stroke and congestive HF was reduced among women older than 50 years who underwent hysterectomy compared with controls. No associations were observed between CVD and hysterectomy among women aged 36 to 50 years.
“Our study extends the evidence for an association between hysterectomy with ovarian conservation and pre-existing CV risk factors and CVDs,” the researchers concluded. “Our findings may stimulate the engagement of gynecologists in preventing CVD. Women who are candidates for hysterectomy may have comorbidities in addition to obesity and should undergo diagnostic tests and preventive interventions, when indicated.” – by Adam Taliercio
Disclosure: The researchers report no relevant financial disclosures.
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