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MitraClip reduced in-hospital MACCE in real-world population
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The MitraClip device yielded low rates of in-hospital mortality rates and procedural complications in a cohort of patients in Germany, according to recent findings.
The researchers culled data from 828 patients enrolled in the prospective German Transcatheter Mitral Valve Interventions registry to determine complication rates associated with MitraClip (Abbott Vascular) implantation.
Eligible participants underwent the procedure between 2010 and 2013. Elective procedures were performed in 85% of the cohort. Patients were treated with an average of 1.4 ± 0.6 clips and did not require emergent cardiac surgery. There was one intraoperative fatality.
The in-hospital complication rate was 25.9%. Major complications were reported in 12.8% of patients.
The most frequently reported major complication was bleeding, which occurred in 7.4% of patients. Pericardial tamponade occurred in 1.9% of the cohort, 1.9% experienced partial clip detachment and 0% experienced embolization.
In-hospital major adverse cardiac and cerebrovascular events occurred in 2.7% of the population, including all-cause death in 2.2%, stroke in 0.9% and MI in 0% of patients.
Older patients were more likely to experience complications, as were those who were critically ill before the procedure. In-hospital mortality was 8.3% among patients with procedural complications vs. 0% for those with no complications.
Early surgery was performed in 0.9% of patients, whereas 0.6% required a second MitraClip implantation.
“MitraClip implantation appeared to be a safe treatment option, with low rates of in-hospital MACCE and clip-specific complications,” the researchers concluded. “Nevertheless, MitraClip is not without complications, and patients with complications are at increased risk for postprocedural death. Therefore, careful patient selection, appropriate timing of the procedure as well as strategies for reducing post-interventional bleeding have the potential of reducing complications and improving outcomes.” – by Rob Volansky
Disclosure: The researchers report receiving research grants, travel grants and speakers’ bureau fees from Abbott Vascular.
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