September 21, 2015
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Stenting outperforms angioplasty in PAD

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Compared with angioplasty, endovascular stenting for treatment of peripheral artery disease yielded lower rates of postprocedural complications and amputation with only a minimal increase in hospitalization costs, according to results published in the American Journal of Cardiology.

“The comparative data for angioplasty and stenting for treatment of [PAD] are largely limited to technical factors such as patency rates with sparse data on clinical outcomes like mortality, postprocedural complications and amputation,” the researchers wrote.

To better understand the comparative efficacy of the procedures, researchers at several U.S. institutions analyzed peripheral endovascular interventions from the Healthcare Cost and Utilization Project Nationwide Inpatient Sample database from 2006 to 2011.

In all, 44,399 patients received angioplasty and 48,248 received stenting. Age was similar between the groups.

In-hospital mortality served as the primary outcome measure, and a composite of in-hospital mortality and postprocedural complications served as the secondary outcome measure. Amputation rates and hospitalization costs were also evaluated.

Although the primary outcome was similar between groups, patients who underwent endovascular stenting had lower rates of the secondary outcome (OR = 0.96; P = .025) and amputation (OR = 0.56; P < .001) compared with angioplasty alone.

In multivariate analysis, stenting was associated with higher hospitalization costs ($1,516; P < .001) vs. angioplasty.

The researchers noted that the marginal increase in hospitalization cost in the stenting arm must be must be counterweighed against the substantial improvement in clinical outcomes.

“Additional studies evaluating the long-term outcomes of endovascular stenting might further aid in understanding the economics of this minimal increase in initial hospitalization costs with endovascular stenting,” they wrote. – by Brian Ellis

Disclosure: The researchers report no relevant financial disclosures.