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TREAT
Trial to Reduce CV Events with Aranesp Therapy
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Trial assessed eff ects of darbepoetin alfa vs. placebo for reduction in composite of death, MI, unstable angina, HF or stroke in patients with type 2 diabetes, chronic kidney disease and concomitant anemia.
Design: randomized, placebo-controlled
Patients: 4,038
Centers: 634
Countries: 24
RESULTS: The composite endpoint of death, MI, myocardial ischemia, HF and stroke was similar in the darbepoetin alfa group (n=2,012) vs. placebo (n=2,026; 31.4% vs. 29.7%; HR=1.05; 95% CI, 0.94-1.17). Component endpoints were also similar between the two groups, including death (20.5% vs. 19.5%, P=.48), HF (10.2% vs. 11.3%, P=.24), MI (6.2% vs. 6.4%, P=.73) and myocardial ischemia (2.0% vs. 2.4%, P=.40). For the component endpoint of stroke, there was an increase in the darbepoetin group vs. placebo (5.0% vs. 2.6%, P<.001). There was no difference in the composite renal endpoint (32.4% darbepoetin vs. 30.5% placebo, P=.29) and there was no difference in end-stage renal disease (16.8% vs. 16.3%, P=.83).
Presented at AHA 2009.
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