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FOCUS
Functional Outcomes in Cardiovascular Patients Undergoing Surgical Hip Fracture Repair
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Trial evaluated eff ects of 10 g/dL infusion strategy vs. conventional symptomatic infusion strategy on patient outcomes and hemoglobin levels.
Design: randomized
Patients: 2,016
Centers: 47
Countries: United States, Canada
RESULTS: A total of 977 patients (97%) in the non-symptomatic strategy group received transfusions, compared with 419 patients (41.5%) in the symptomatic group. There were no differences between the 10 g/dL treatment group and symptomatic treatment group for elevated troponin levels (6.2% vs. 5.9%; OR=1.06; 99% CI, 0.65-1.71), in-hospital MI (2.3% vs. 3.8%; OR=0.60; 99% CI, 0.30-1.19), in-hospital mortality (2.0% vs. 1.4%; OR=1.44; 99% CI, 0.58-3.56), cardiac mortality (0.7% vs. 0.5%; OR=1.41; 99% CI, 0.31-6.39) or the combined endpoint of MI, unstable angina or death (4.3% vs. 5.2%; OR=0.82; 99% CI, 0.48-1.42). There were 1,866 transfused blood units in the 10 g/dL group vs. 652 units in the symptomatic group.
Presented at AHA 2009.
Click here to read more about the FOCUS trial.