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DOSE
Diuretic Optimization Strategies Evaluation in Acute Heart Failure
Trial assessed effect of both high and low doses of furosemide administered either continuously or every 12 hours on fluid overload in patients with acute decompensated HF.
Design: randomized
Patients: 308
Centers: multicenter
Country: United States
RESULTS: A trend toward greater symptom resolution in patients receiving the high dose over 72 hours (P=.06), whose median change in creatinine from baseline to 72 hours was 0.06 mg/dL in the high-dose group vs. 0.01 mg/dL in the low-dose group (P=.21), was reported. Secondary endpoints such as change in weight at 72 hours (low dose, –5.3 lb vs. high dose, –8.2 lb; P=.011), net volume loss at 72 hours (low dose, 3,575 mL vs. high-dose, 4,899 mL; P<.001) and percentage with creatinine increase >0.3 mg/dL at 72 hours (low-dose, 14% vs. highdose, 23%; P=.041) also tended to favor high-dose furosemide.
Presented at ACC 2010.
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