This article is more than 5 years old. Information may no longer be current.
AF before TAVR linked with poorer outcomes
Click Here to Manage Email Alerts
Among patients undergoing transcatheter aortic valve replacement, prior atrial fibrillation was associated with a nearly threefold increase in risk for adverse outcomes, according to recent findings.
The researchers aimed to evaluate the extent to which AF impacts procedural outcomes in TAVR in a cohort of 137 patients with severe aortic stenosis.
Eligible participants underwent the procedure using the Sapien transcatheter valve (Edwards Lifesciences).
The researchers assessed factors that predicted new-onset AF, including post-procedural outcomes and adverse events with a focus on the presence or absence of previous or post-procedural AF.
Forty-nine percent of the cohort demonstrated AF before TAVR. New-onset AF was reported in 21% of patients after TAVR. The cumulative incidence of post-procedural AF was 60%, according to the results.
Half of the episodes of new-onset AF occurred within 24 hours of TAVR.
New-onset AF occurred more frequently among patients who underwent transapical TAVR (adjusted OR=5.05; 95% CI, 1.40-18.20).
Patients with prior AF were significantly more likely to experience the composite outcome of all-cause death, stroke, vascular complications and repeat hospitalizations at 1 month than patients who did not previously have AF (adjusted OR=2.60; 95% CI, 1.22-5.54).
Patients who experienced AF after TAVR stayed in the ICU an average of 70 hours longer than patients without AF (95% CI, 25-114.7). Patients with AF also stayed in the hospital longer, with an increased duration of 6.7 days (95% CI, 4.69-8.73).
Disclosure: The researchers report financial disclosures with Astellas/Cardiome, Biosense Webster, Biotronik, Boston Scientific, Bristol-Myers Squibb, Cardiofocus, CardioInsight, Edwards Lifesciences, InfoBionic-Scientific, Mast Therapeutics, Medtronic, Pfizer, Portola, Sanofi, Sorin, St. Jude Medical, Thrasos, Voyage Medical and World Care Clinical.
Click Here to Manage Email Alerts