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Sjögren’s syndrome increased risk for MI

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Patients with Sjögren’s syndrome have an elevated risk for MI, particularly in the first year after diagnosis, researchers reported at the European League Against Rheumatism Annual Congress.

The population-based cohort study compared the RR for MI and stroke in patients with newly diagnosed Sjögren’s syndrome (MI cohort=1,176; stroke cohort=1,195) vs. healthy controls (MI cohort=11,879; stroke cohort=11,983). Researchers analyzed physician billing and hospitalization databases covering the entire population of British Columbia, Vancouver, incorporating visits to health professionals and hospitalizations between 1990 and 2010 and medications dispensed between 1995 and 2010.

According to results presented, the incidence rate of first-time MI was 7.7 per 1,000 person-years among patients with Sjögren’s syndrome compared with 3.5 per 1,000 person-years among controls (RR=2.2; 95% CI, 1.41-2.32).

The incidence rate of first-time stroke was 5.1 per 1,000 person-years among patients with Sjögren’s syndrome compared with 3.4 per 1,000 person-years among controls (RR=1.5; 95% CI, 0.9-2.4). Adjustment for other CVD risk factors did not alter the results.

The risk for developing MI was highest during the first year after diagnosis of Sjögren’s syndrome (RR=3.6; 95% CI, 1.6-7.3). Risk declined in subsequent years and was no longer statistically significant at 5 years after diagnosis. The researchers did not observe a similar pattern in risk for stroke.

“Our results support the role of inflammation in [CVD] and the need for increased monitoring for [CAD] in all patients with this condition, in addition to proper management and modification of their [CV] risk factors to reduce the risk of a future heart attack,” Antonio Aviña-Zubieta, MD, MSc, PhD, of the University of British Columbia, Vancouver, said in a press release.

For more information:

Yurkovich M. Abstract OP0212. Presented at: the European League Against Rheumatism Annual Congress; June 11-14, 2014; Paris.

Disclosure: Aviña-Zubieta reports no relevant financial disclosures.