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Revascularization reduced need for PAD-related amputations in 20-year study

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Among patients with peripheral arterial disease, the incidence of amputations significantly decreased as the use of limb revascularization increased, according to research presented at the Society for Vascular Surgery’s 2013 Vascular Annual Meeting.

In the 20-year study including data from 1990 to 2009, researchers at Mayo Clinic reported a 40% decrease in the need for amputations while an increase in revascularization procedures in patients with PAD also occurred during this period.

The population-based cohort study was conducted in 773 patients who underwent 1,906 limb revascularization procedures. All were participants in the Rochester Epidemiology Project, a NIH-funded medical records pool. The mean age of the patients was 68 years. Most patients were white (96.5%) and male (58.5%).

The researchers observed a significant decrease in 5-year incidence rates of open surgical revascularization and amputations while significant increases were recorded in total revascularization, endovascular revascularization and hybrid (both total and endovascular) revascularization. The incidence of total revascularization increased from 91 to 118 per 100,000 patient-years (P=.0014) and amputations decreased from 21 to 13 per 100,000 person-years (P=.0123). Primary amputations decreased from 13 to 5 per 100,000 person-years (P=.0002), according to study results.

“This is an important study because frequently patients who have peripheral arterial disease … may progress to amputation,” Peter Gloviczki, MD, Mayo Clinic vascular surgeon and past president of the Society for Vascular Surgery, stated in a press release. “This study shows that the use of endovascular interventions — stents, balloons or other catheter-based interventions — or open surgical bypass effectively reduced the amputation rate.”

For more information:

Nienaber J. Abstract PS128. Presented at: the Society for Vascular Surgery’s Vascular Annual Meeting; May 29-June 1, 2013; San Francisco.

Disclosure: Gloviczski reports no relevant financial disclosures.