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Angina not associated with CV events, death in diabetic patients
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A post-hoc analysis of the BARI 2D trial found that patients with type 2 diabetes, stable CAD and documented myocardial ischemia were at similar risk for CV events and death regardless of whether they had angina, angina equivalents or were asymptomatic.
The analysis included 2,364 patients with type 2 diabetes and documented CAD enrolled in the BARI 2D trial. The cohort had 1,434 patients with angina, 506 with angina equivalents and 424 with neither. All patients had suitable coronary anatomy for randomization into either PCI or CABG strata.
Cumulative death rates among 316 patients were 12% in angina, 14% in angina equivalents and 10% in neither (P=.30). For 548 CV composite rates, there were 24% in patients with angina, 24% in patients with angina equivalents and 21% in those with neither (P=.50).
HRs adjusted for confounders were similar for death in angina compared with patients with neither (HR=1.11; 99% CI, 0.81-1.53) and angina equivalents compared with neither (HR=1.17; 99% CI, 0.81-1.68) or for CV events in angina (HR=1.17; 99% CI, 0.92-1.50) and angina equivalents (HR=1.11; 99% CI, 0.84-1.48).
Researchers noted that these patients may be similarly managed in terms of risk stratification and preventive therapies.
“Considering the whole spectrum of silent ischemia in patients with type 2 diabetes, these findings are consistent with the similar survival rates between patients with diabetes with unrecognized MI and those with recognized MI,” they wrote.
Disclosure: The researchers report no relevant financial disclosures.
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