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PET, CMR appeared comparable, accurate for detection of acute CAD
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Researchers have found good correlation between cardiac magnetic resonance-derived myocardial perfusion reserve measurements and PET-derived myocardial perfusion reserve measurements in patients with CAD, according to recent research published in the Journal of the American College of Cardiology. Both were found comparable and accurate in the detection of significant CAD.
For this study, researchers compared fully quantitative cardiac magnetic resonance (CMR) and PET myocardial perfusion and myocardial perfusion reserve (MPR) measurements in 41 patients with suspected or known CAD. The patients underwent quantitative 13N-ammonia PET and CMR perfusion imaging before coronary angiography.
The CMR-derived and the PET-derived MPR measurements had a good correlation (r=0.75; P<.0001), including for the two lowest scoring segments in each coronary territory (r=0.79; P<.0001). However, absolute CMR perfusion values correlated significantly, but weakly, with PET values at rest (r=0.32; P=.002) and during stress (r=0.37; P<.0001).
In the detection of significant CAD, area under the receiver-operating characteristic curve for PET-derived MPR was 0.83 (95% CI, 0.73-0.94) and 0.83 for CMR-derived MPR (95% CI, 0.74-0.92). Researchers also found that PET-derived MPR ≤1.44 predicted significant CAD with 82% sensitivity and 87% specificity. Similarly, CMR-derived MPR ≤1.45 predicted significant CAD with 82% sensitivity and 81% specificity.
“There is a strong correlation between MPR derived from quantitative CMR and PET data, which is important given the proven value of MPR PET for detection of CAD, prognostication, and assessment of the microcirculation. The MPR PET and MPR CMR seem to predict significant CAD equally well and accurately. However, in patients, the absolute perfusion values from PET and CMR are only weakly correlated, suggesting that further refinement of quantitative techniques is required,” the researchers wrote in the conclusion.
Disclosure: See the study for a full list of researchers’ disclosures.
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