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NSAID use heightens CV risk after first-time MI
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After 5 years of follow-up, researchers for a new study found that use of nonsteroidal anti-inflammatory drugs was associated with increased CV risk regardless of time passed after a first-time MI.
The nationwide cohort study included 99,187 patients aged at least 30 years included in nationwide registries of hospitalization and drug dispensing from pharmacies in Denmark. All patients had a first-time MI from 1997 to 2009 and subsequent NSAID use. Researchers then calculated incidence rates of death and a composite endpoint of coronary death or nonfatal recurrent MIs associated with NSAID use each year for 5 years.
Forty-four percent of patients filled at least one NSAID prescription. Among those receiving a NSAID, risk for death from any cause was 59% higher 1 year after their MI and 63% higher after 5 years. Similarly, risk for recurrent MI or coronary death was 30% higher 1 year after their MI and 41% higher after 5 years, according to a press release.
The data revealed no difference between men vs. women.
“These results support previous findings that NSAIDs have no apparent safe treatment window among patients with MI. Further studies are warranted to evaluate the CV safety of NSAIDs, but at this point the overall evidence suggests advising caution in using NSAIDs at all times after MI,” the researchers concluded.
Disclosure: Schjerning Olsen reports receiving an unrestricted grant from the department of cardiology, Copenhagen University Hospital Gentofte, Denmark. The funding source had no influence on study design, interpretation of the results or the decision to submit the article. All other researchers reported no relevant financial disclosures.
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