This article is more than 5 years old. Information may no longer be current.
Post-PCI bleeding associated with major adverse events in older patients
Click Here to Manage Email Alerts
Among older patients, post-PCI bleeding resulted in an increased risk for short- and long-term recurrent bleeding, MACE and all-cause mortality in a recent study.
“Thus, post-procedure bleeding identifies a patient population that is at risk for poor net adverse clinical events,” the researchers wrote.
In the study, investigators from four institutions in the United States linked 461,311patients (mean age, 74 years) undergoing PCI from the National Cardiovascular Data Registry CathPCI Registry from 2004 to 2008 to claims of in-hospital post-PCI bleeding from CMS.
Overall, 3.1% of patients experienced post-PCI bleeding. Patients who bled were more likely to be older, female, undergo PCI via the femoral approach and have medical comorbidities, and less likely to receive bivalirudin (Angiomax, The Medicines Company).
Bleeding after PCI was significantly associated with readmission for bleeding at 1 month (adjusted HR=1.54; 95% CI, 1.42-1.67), 12 months (adjusted HR=1.52; 95% CI, 1.4-1.66) and 30 months (adjusted HR=1.29; 95% CI, 1.11-1.5), and MACE at 1 month (adjusted HR=1.11; 95% CI, 1.07-1.15), 12 months (adjusted HR=1.17; 95% CI, 1.13-1.21) and 30 months (adjusted HR=1.12; 95% CI, 1.06-1.19). In addition, post-PCI bleeding was also significantly linked to all-cause mortality at 1 month (adjusted HR=1.32; 95% CI, 1.26-1.38), 12 months (adjusted HR=1.33; 95% CI, 1.27-1.4) and 30 months (adjusted HR=1.22; 95% CI, 1.15-1.3).
Click Here to Manage Email Alerts