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Depression ups risk for PAD in patients with CAD

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Depressed patients with coronary artery disease may be more likely to develop peripheral arterial disease, according to study results presented at the 2012 Arteriosclerosis, Thrombosis and Vascular Biology Scientific Sessions.

Using data from the Heart and Soul Study, researchers followed 1,024 men and women with CAD recruited from 2000 to 2002 for a mean of 7.2 years. They determined prevalent PAD by patient self-report.

 Study results showed 19% of patients were affected by depression at baseline. Approximately 12% of those with vs. 7.3% of those without depression had prevalent PAD (age-adjusted OR=1.79; 95% CI, 1.06-3.03). Physical inactivity, diabetes and C-reactive protein levels explained more than 5% of the association between depression and prevalent PAD in age-adjusted models.

Nine percent of patients with depression vs. 6% without experienced PAD events during follow-up (age-adjusted HR=1.77; 95% CI, 1.02-3.07). More than 5% of the association between depression and incident PAD events were explained by inactivity, diabetes, prevalent PAD, race/ethnicity, smoking, HDL and triglyceride levels.

“Since elevations in traditional, modifiable CV risk factors partially explain these associations, such risk factors should be assessed and aggressively treated,” the researchers said. “Furthermore, this study emphasizes the importance of depression screening and treatment in patients with PAD.”

For more information:

• Grenon SM. Abstract #418. Presented at: The Arteriosclerosis, Thrombosis and Vascular Biology 2012 Scientific Sessions. April 18-20, 2012; Chicago.

Disclosure: The researchers report no relevant financial disclosures.