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Vitamin D-fortified yogurt drink reduced inflammation in type 2 diabetes
Patients with diabetes who consume a vitamin D-fortified Persian yogurt drink, known as “doogh,” may experience improved inflammatory markers and, therefore, a lower risk for CVD, according to researchers from Shahid Beheshti University of Medical Sciences in Tehran, Iran.
During a 12-week, double blind, randomized, controlled trial, researcher Tirang Neyestani, PhD, and colleagues examined 90 men and women aged 30 to 60 years with type 2 diabetes. Some participants (73.3%) had vitamin D deficiency and insufficiency.
Each participant was randomly assigned to one of three groups. Participants were given two 250-mL bottles per day of plain doogh containing 150 mg calcium and no detectable vitamin D3/250 mL (PD group); vitamin D-fortified doogh containing 500 IU vitamin D3 and 150 mg calcium/250 mL (DD group); or calcium plus vitamin D3-fortified doogh, containing 500 IU vitamin D3 and 250 mg calcium/250 mL (CDD group).
“Our study showed for the first time that adiponectin … increased when calcium and vitamin D-fortified doogh was consumed,” Neyestani said in a press release. “Our findings may offer interesting therapeutic options for diabetic patients.”
Researchers wrote that the daily intake of 1,000 IU vitamin D, with or without calcium for 12 weeks, caused a significant decrease of serum highly sensitive C-reactive protein and plasma fibrinogen concentrations. The researchers also concluded that it was associated with improvement in serum adipokines, including adiponectin and retinol binding protein, and decreased cellular secretion of inflammatory cytokines interleukin-6 and IL-1 beta among participants.
Both DD and CDD groups displayed improved vitamin D status, according to the researchers. The average adiponectin changes in the CDD group were considerably higher than in the PD group (P=.021), and the difference remained after controlling for fat mass and age (P=.015).
Additional studies are required to determine the long-term effects of the intervention, the researchers said.
Disclosure: The researchers report no relevant financial disclosures.