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Psoriasis risk factor for AF, stroke, MI

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American College of Cardiology 59th Annual Scientific Sessions

ATLANTA – Using data from a 10-year Denmark registry of more than 40,000 patients, researchers concluded that psoriasis is a risk factor for AF, stroke, MI, angioplasty and cardiac death, according to data released here on Saturday.

“Our results establish psoriasis as a clinically significant and independent risk factor for a range of CV events,” Ole Ahleoff, MD, of Copenhagen University Hospital Gentofte, Denmark, said in a press release.

The registry tracked hospital visits and prescriptions of 40,252 adolescent and adult patients with mild-to-severe psoriasis for more than 10 years (1997 to 2006). According to the release, researchers believed there was a link between psoriasis and CV events because both have severe, associated inflammation.

The researchers reported that psoriasis was associated with increased risk for AF in mild symptoms (RR=1.22) and moderate-to-severe symptoms (RR=1.51). Also, psoriasis was associated with increased risk for stroke in mild symptoms (RR=1.19) and moderate-to-severe symptoms (RR=1.45).

Patients with moderate-to-severe symptoms who were aged younger than 50 years at the study start had increased risk for AF (RR=2.28) and stroke (RR=1.92). Patients with moderate-to-severe symptoms also had increased risk for MI (RR=1.24) vs. those patients with mild symptoms (RR=1.10), according to the release.

Moreover, mild symptoms (RR=1.29) and moderate-to-severe symptoms (RR=1.59) increased the risk for angioplasty.

“I believe our results call for increased awareness of psoriasis as a contributor to CVD and for a discussion of future medical management,” Ahlehoff said in the release.

The Copenhagen University Hospital Department of Cardiology funded this study.

For more information:

• Ahlehoff O. Psoriasis is a risk factor for atrial fibrillation and stroke: a Danish nationwide cohort study. Presented at: American College of Cardiology 59th Annual Scientific Sessions; March 13-16, 2010; Atlanta.

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