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PROSPECT
Providing Regional Observations to Study Predictors of Events in the Coronary Tree
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Trial set out to determine the natural history of coronary atherosclerosis by using multimodality intravascular imaging to identify clinical and lesion-related factors that place patients with ACS at risk for adverse cardiac events.
Design: prospective
Patients: 697
Centers:
multicenter
Countries: United States and Europe
Results: Three-year cumulative adverse CV event rate was 20.4%, with culprit lesions related to 12.9% of the cases in patients and nonculprit lesions 11.6%. After multivariate analysis nonculprit lesions that were associated with recurrent events were found to be more likely than those not associated to be characterized by plaque burden of at least 70% (HR=5.03; 95% CI, 2.51-10.11), a minimal luminal area of 4 mm2 or less (HR=3.21; 95% CI, 1.61-6.42) or to be classified by radiofrequency intravascular ultrasonography as thin-cap fibroatheromas (HR=3.35; 95% CI, 1.77-6.36).
Read more about the PROSPECT trial here.
Published in: N Engl J Med. 2011;364:226-235.