PCI linked to high-risk serious adverse events

European Society of Cardiology Congress 2011

Percutaneous coronary intervention was associated with significantly higher risk for serious adverse events in triple-vessel coronary artery disease vs. CABG, new study results indicated.

Among 15,263 patients with first coronary revascularization enrolled in the CREDO-Kyoto PCI/CABG registry cohort-2, 2,981 patients were identified with triple-vessel CAD. Anatomic complexities of CAD were assessed by researchers using the SYNTAX score to ensure comparability between PCI and CABG. The study’s primary endpoint was a composite of all-cause death, MI and stroke.

Patients with low and intermediate SYNTAX scores had the same cumulative incidence of the primary endpoint between PCI and CABG groups vs. a higher cumulative incidence following PCI than after CABG for patients with a high SYNTAX score. The risk for all-cause and cardiac death was also significantly higher after PCI. The adjusted risk for the primary endpoint of PCI relative to CABG was 1.66 in the low-score category, 1.24 in the intermediate-score category and 1.59 in the high-score category, according to researchers.

In a press release, Hiroki Shiomi, MD, of Kyoto University Hospital in Japan, noted that “CABG would still remain the standard treatment option in patients with triple-vessel disease, particularly when then SYNTAX scores are high.”

Results of the trial were presented at the European Society of Cardiology Congress 2011 in Paris.

For more information:

Hiroki S. Hotline II. Presented at: European Society of Cardiology Congress 2011; Aug. 27-31; Paris.

Disclosure: Dr. Shiomi reports no relevant financial disclosures.

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