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Overweight diabetics can improve CRP levels with nutrition, exercise
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American Heart Association Scientific Sessions 2010
CHICAGO — Patients with type 2 diabetes who engage in lifestyle behaviors aimed at weight loss and improved glucose control may also improve their high-sensitivity C-reactive protein levels, data suggest.
Researchers measured CRP levels at baseline and at 1 year in 1,759 patients with diabetes who were enrolled in the Look AHEAD (Action for Health in Diabetes) study. Look AHEAD is a multicenter clinical trial evaluating the effects of improved lifestyle behavior for weight loss on CVD in overweight and obese people with diabetes in the United States. Participants were randomly assigned to receive either lifestyle intervention or usual care. The lifestyle intervention group received frequent counseling to increase moderate-intensity exercise to 175 minutes per week and reduce caloric intake; the usual care group received three information sessions in the year. Forty percent of participants were taking statin therapy at baseline.
At baseline, the patients’ mean CRP level was 4.2 mg/dL. Results showed that lifestyle intervention reduced the average CRP level by 43.6% compared with a 16.7% reduction with usual care. In addition, researchers found a significant reduction in CRP levels with lifestyle intervention in both statin and non-statin users when compared with the usual care group.
The researchers concluded that “efforts to improve lifestyle behaviors may be beneficial in patients who are taking statins and still have elevated levels of CRP.”
For more information:
- Belalcazar LM. Abstract 14666. Presented at: American Heart Association Scientific Sessions 2010; Nov. 13-17; Chicago.
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