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Acute, hospital-acquired anemia found common in patients with acute MI
Salisbury AC. Circ Cardiovasc Qual Outcomes. 2010;3:337-346.
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Nearly half of the patients with acute MI who were treated medically or with percutaneous coronary intervention developed acute, hospital-acquired anemia, according to the outcomes of a new study.
Researchers identified patients (≥18 years, n=2,909) with acute MI who had normal hemoglobin on admission in the TRIUMPH multicenter registry. They used criteria proposed by Beutler and Waalen to define acute, hospital-acquired anemia (HAA), and they identified independent correlates of HAA and multivariable proportional hazards regression to identify the relationship between HAA and mortality and health status.
Of the study patients, 1,321 (45.4%) had HAA, with 348 (26.3%) developing moderate-severe HAA (hemoglobin <11 g/dL). Incidence of HAA varied across hospitals (range, 33%-69%; median rate ratio for HAA, 1.13; 95% CI, 1.07-1.23). Fewer than half of the patients with moderate-severe HAA had documented bleeding, although documented bleeding was more frequent with more severe HAA.
Researchers determined the following as independent correlates of HAA: age, female sex, white race, STEMI, chronic kidney disease, acute renal failure, use of glycoprotein IIb/IIIa inhibitors, in-hospital complications and length of stay.
“We found that HAA is common in acute MI patients who are treated medically or with PCI and varies significantly across hospitals,” the researcher concluded. “Development of moderate-severe HAA is associated with higher mortality and worse health status in the first year after acute MI, independent of documented in-hospital bleeding. Better understanding of whether prevention of HAA is feasible and can improve patient outcomes is needed.”
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