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WISE
Women’s Ischemia Syndrome Evaluation
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Trial assessed whether evidence of myocardial ischemia occurs in the absence of obstructive coronary artery disease in women.
Design: diagnostic
Patients: 189
Centers: multicenter
Country: United States
RESULTS: During follow-up, 79 women (42%) had an adverse outcome, and there were 138 events, which included 11 deaths. An exploratory receiver-operator characteristic analysis suggested that coronary flow reserve <2.32 was the best discriminating threshold for adverse outcomes (event rate, 26.7%; and >2.32 event rate, 12.2%; P=.01). Lower coronary flow reserve was associated with increased risk for major adverse outcomes (HR=1.16; 95% CI, 1.04-1.30), a finding that held true among the 152 women without obstructive CAD (HR=1.20; 95% CI, 1.05-1.38).
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Published in: J Am Coll Cardiol. 2010;55:2825-2832.