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SNPs identified for elevating risk of hypertension in Japanese patients
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Data from the Japanese Millennium Genome Project suggests an association between single nucleotide polymorphisms located in the ATP2B1 gene region, particularly rs2070759 and rs11105378, and an increased susceptibility for hypertension in a Japanese study population
The study included Japanese individuals (n=14,105) from seven independent study cohorts. Researchers studied hypertensive and normotensive participants to determine the single nucleotide polymorphisms (SNPs) that were most associated with hypertension.
According to study data, the analysis revealed that the SNP most associated with hypertension was ATP2B1 rs11105378 (P=4.1×10-11). There was also a relationship between rs2070759 and hypertension, but to a lesser extent (P=5.3×10-5).
Additionally, researchers cross-validated the relationship between rs11105378 and hypertension by replication analysis with the Global Blood Pressure Genetics consortium data set, which also revealed an association (P=5.9×10-4).
This study, they wrote, “has identified SNPs located upstream or within the ATP2B1 gene as strong susceptibility polymorphisms for hypertension in Japanese. These are findings that have also been reported recently in individuals of European descent and in Koreans.”
Tabara Y. Hypertension. 2010;doi:10.1161/HYPERTENSIONAHA.110.153429.