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SIMA: Stenting and CABG yielded similar long-term clinical outcomes
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Intracoronary stent implantation and CABG performed in patients with isolated proximal left anterior descending coronary arteries yielded comparable clinical outcomes at 10 years.
Researchers for the Stent Versus Internal Mammary Artery Grafting (SIMA) trial enrolled 123 patients with isolated proximal LAD coronary artery stenosis and left ventricular ejection fraction >45% into the randomized trial. Two patients were excluded, leaving 121 for analysis. Patients were then assigned to either stenting (n=62) or CABG (n=59).
The researchers reported no difference between stenting and CABG in reaching the primary composite endpoint of all-cause death, MI and additional revascularization at 30 days (7% vs. 4%). At 10 years, the primary endpoint was reached more frequently in the group assigned to stents than in the CABG group, whereas mortality and MI were not statistically different between the two groups, according to the researchers. Revascularization was required in 15 (25%) of the patients in the stenting group vs. none in the CABG group (P<.001).
For more information:
- J Am Coll Cardiol. 2008;52:815-817.