Issue: March 2010
March 01, 2010
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POPE
Post Operative Pericardial Effusion
Issue: March 2010
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Trial was conducted to assess effects of the NSAID diclofenac on size of postoperative pericardial effusion.
Design: randomized, double blind
Patients: 196
Centers: multicenter
Country: France
RESULTS: The mean change for pericardial effusion from baseline was –1.08 grades in the placebo group vs. –1.36 in the diclofenac group (P=.11). Diclofenac did not modify the secondary study endpoint of tamponade frequency (P=.49). The mean change in pericardial effusion width was –4.8 mm in the placebo group vs. –6.7 mm in the diclofenac group, with a –1.92-mm mean difference between groups (P=.07).
Published in: Ann Intern Med. 2010;152:137-143.
Click here to read more about the POPE trial.