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Iron deficiency not linked to CV, all-cause mortality
Parikh A. Circ Heart Fail. 2011;doi:10.1161/circheartfailure.111.960906.
An analysis of the Third National Health and Nutrition Examination Survey has indicated that iron deficiency among those with self-reported HF, although prevalent, was not associated with CV or all-cause mortality.
In all, researchers looked at 574 community-dwelling adults with self-reported HF to examine the role of iron deficiency, CRP and hemoglobin in mortality. They defined functional and absolute iron deficiency as ferritin levels of less than 100 mcg/L or between 100 mcg/L and 299 mcg/L if the transferrin saturation was less than 20%.
According to results, 61.3% of adults had iron deficiency, which was linked with reduced hemoglobin (13.6 vs. 14.2 g/dL; P=.007) and increased CRP (0.95 vs. 0.63 mg/dL; P=.04).
During follow-up (median, 6.7 years), 52.3% of adults died, of whom 33.6% died of CV causes. Although multivariate analysis revealed CRP to be associated with all-cause (P<.0001) and CV (P=.01) mortality and hemoglobin to be associated with CV mortality (P=.04), there was no correlation between iron deficiency and either CV (P=.81) or all-cause mortality (P=.50).
“Our data do not support a direct relationship between iron deficiency and mortality in community-dwelling US adults with self-reported HF,” the researchers concluded. “Further work is needed to determine the long-term effects of iron therapy in the HF population.”
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