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Higher LDL linked to increased incidence of metabolic syndrome
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Higher concentration of LDL was associated with increased incidence of metabolic syndrome, abdominal obesity, hyperglycemia and high triglyceride levels, according to the findings from a recent study.
Researchers from Belgium and the University of Minnesota examined data from the Coronary Artery Risk Development in Young Adults study. Participants were aged 18 to 30 years at the time of recruitment in 1985 and 1986 (n=1,889); 41% were black and 56% were women. Participants lived in one of four metropolitan areas. They were seen between 2000 and 2001 and between 2005 and 2006.
Those who were not diagnosed at the 15-year follow-up had metabolic syndrome at the 20-year follow up (12.9%). The adjusted odds ratio for metabolic syndrome after five years of follow-up was 2.1 for the second quintile (95% CI; 1.1-3.8), 2.4 for the third quintile (95% CI, 1.3-4.3), 2.8 for the fourth quintile (95% CI, 1.5-5.1) and 3.5 for the fifth quintile (95% CI, 1.9-6.6).
The adjusted odds ratio for incidence of dichotomous components of metabolic syndrome in the highest vs. the lowest quintile for LDL were 2.1 (95% CI, 1.2-3.6) for abdominal obesity, 2.4 (95% CI, 1.5-3.8) for high fasting glucose and 2.1(95% CI, 1.1-4.0) for high triglycerides, according to the study. – by Christen Haigh
JAMA. 2008;299:2287-2293.