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FAIR-HF

Ferric Carboxymaltose Assessment in Patients with Iron Deficiency and Chronic HF With and Without Anemia

Issue: January 2010

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Trial assessed intravenous infusion of ferric carboxymaltose vs. placebo in patients with chronic HF and iron deficiency.

Design: randomized, double blind
Patients: 459
Centers: multicenter
Countries: 10

RESULTS: Patient Global Assessment at 24 weeks improved in the ferric carboxymaltose group, with 50% of patients reporting either much improved or moderately improved scores vs. 27% in the placebo group (OR=2.51; 95% CI, 1.75-3.61). In addition, NYHA functional class improved in the ferrous carboxymaltose group, with 47% of patients reporting NYHA functional class I or II vs. 30% in the placebo group (OR=2.40; 95% CI, 1.55-3.71). There was also an improvement in six-minute walking distance at four weeks (P<.001), 12 weeks (P<.001) and 24 weeks (P<.001) in the ferric carboxymaltose group. No interactions between secondary endpoints were reported.

Presented at AHA 2009.

Click here to read more about the FAIR-HF trial.