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Dual-source CTA comparable with catheter angiogram for CAD diagnosis
Correlation between results from dual-source CTA and catheter angiography was reported.
Coronary CT performed on a dual-source CT scanner demonstrated a highly positive and negative predictive value in determining significant coronary artery disease, study results suggested.
The researchers enrolled 890 consecutive patients into the study between January 2007 and October 2008, 210 of whom had significant CAD (defined as stenosis >70%). None of the patients received beta-blockers. The patients were scanned using a Siemens Definition dual-source CT scanner. Following acquisition, 38 patients underwent correlative catheter angiogram, and two radiologists conducted a blind study in which the CTA results were compared with the catheter angiogram results.
One hundred fifty lesions were studied, and the researchers reported a positive predictive value of 96%. Seven of the 150 lesions were underestimated, four were overestimated and three were missed under CTA. The negative predictive value of the scans was about 100% with a specificity of 67%, and a correlation between the results of the catheter coronary angiogram and the coronary CTA was observed (P=.007), according to the abstract.
“There is an excellent correlation between dual-source CT vs. catheter angiography with a high positive predictive value in the right population,” Rohan S. Kashyape, MD, a radiologist at Breach Candy Hospital in Mumbai, India, said in his presentation at the Radiological Society of North America 94th Scientific Assembly and Annual Meeting in Chicago. “This is an important addition to the already-proven high negative predictive value, and thus it is an important and useful investigation in our armamentarium against CAD.”
For more information:
- Kashyape R. #SSC02-04. Presented at: Radiological Society of North America 94th Scientific Assembly and Annual Meeting; Nov. 30-Dec. 5, 2008; Chicago.