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Dementia documented in one of five patients after first-ever stroke
Béjot Y. Stroke. 2011;42;607-612.
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During a 24-year period, one-fifth of patients developed dementia after their first-ever stroke, according to a new study.
The data for this study were derived from the Dijon Stroke Registry in France, which documented early dementia of patients from 1985 to 2008. For the current study, the 24 years were broken into four time periods: 1985 to 1990, 1991 to 1996, 1997 to 2002, and 2003 to 2008. Although 3,948 first-ever strokes occurred during this time, only 3,201 were testable and included in the investigation.
After analysis, 653 patients (20.4%) were reported as having post-stroke dementia. Temporal trends were found after multivariate analysis, including a significant increase during the fourth time period (OR=1.91; 95% CI, 1.25-2.91) and significant decrease during the second time period (OR=0.52; 95% CI, 0.3-0.9) compared with the first time period. According to researchers, these temporal changes may be explained by concomitant determinants of survival and incidence, such as pre-stroke medication or stroke care management.
Additionally, during the study period, lacunar stroke was seven times more prevalent in patients who experienced post-stroke dementia than intracerebral hemorrhage, although this decreased substantially over time. Other predictors of post-stroke dementia included pre-stroke antiplatelet therapy use, hemiplegia, hypertension and MI (P<.001 for all four), as well as age.
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