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Clopidogrel, aspirin more effective for venous graft patency than aspirin alone
Gao G. J Am Coll Cardiol. 2010;56:1639-1643.
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Short-term trial results after CABG showed more favorable outcomes on venous graft patency for patients given clopidogrel and aspirin than those given aspirin alone.
The single-center, randomized, controlled trial consisted of 249 consecutive patients undergoing CABG from December 2007 to December 2008. The patients were randomly assigned into two groups: those receiving 100 mg aspirin plus 75 mg clopidogrel daily (AC group, n=124) and those receiving 100 mg aspirin-alone daily (A group, n=125). Similar preoperative and intraoperative characteristics were reported at baseline between arms.
At the 3-month follow-up, 224 patients underwent multislice CT angiography. There were no significant differences observed in cardiac-related major adverse events or in intraoperative transit-time flow measurement findings between groups. However, saphenous vein graft patency was shown notably higher in the AC group vs. the A group (91.6% vs. 85.7%; P=.043), which was further substantiated in multivariate analysis (OR=2.00; 95% CI, 1.02-3.92).
“This study shows that the combination of aspirin plus clopidogrel significantly increased venous graft patency at 3 months after CABG compared with aspirin alone,” the researchers wrote, adding that further, long-term studies are needed to confirm the findings.
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