Anti-Arrhythmia Agent

Dofetilide is a class III antiarrhythmic drug. It that is used for maintenance of sinus rhythm in patients with atrial fibrillation.

Ajmaline is a class IA antiarrhythmic drug used diagnostically (not used therapeutically) to elicit ECG changes in patients suspected to have Brugada syndrome.

Disopyramide is a class IA antiarrhythmic drug which acts via blockade of sodium channels depressing phase 0 of the action potential. Disopyramide possesses significant negative inotropic, anticholinergic effects and enhances AV nodal conduction.

Mexiletine is a class IB antiarrhythmic drug used in the treatment of ventricular arrhythmias, specifically ventricular tachycardia and ventricular fibrillation.

Antiarrhythmic drugs act on the electrical conduction system of the heart. The most common use of these drugs is as part of a rhythm control strategy to maintain sinus rhythm. The Vaughan Williams classification system divides these agents based on their mechanisms of action at the cell membrane ― ion channels and sympathetic receptors ― and their effects on the action potential. The classification includes four broad classes, with further subdivisions.

Amiodarone is a class III antiarrhythmic drug, with some class IA properties.

The Vaughan-Williams classification is the system used to categorize antiarrhythmic drug therapy into class IA, class IB, class IC, class II, class III, class IV and class V.

Procainamide is a class I antiarrhythmic drug used in the treatment of atrial fibrillation.

Quinidine is a class I antiarrhythmic drug and is used for the treatment of atrial fibrillation to maintain normal sinus rhythm.

Lidocaine is a class IB antiarrhythmic drug used in the treatment of ventricular arrhythmias, specifically ventricular tachycardia and ventricular fibrillation.