Whole Exome Sequencing

The FDA approved omalizumab so people with immunoglobulin E-mediated food allergies can build tolerance to allergens, but experts warned that the biologic is not a cure.

Whole-exome sequencing helped physicians identify undiagnosed primary immunodeficiency diseases in children with community-acquired sepsis, according to a study published in Pediatric Allergy and Immunology.

Researchers at New York University, Weill Cornell Medicine and New York Genome Center have developed and tested a two-step approach that uses whole-exome sequencing to find genes and pathways that predict response to immunotherapy.

Genomic sequencing of tumors enabled 107 patients with pediatric cancer who experienced relapse to receive an appropriate matched therapy that is not standard of care, according to study results reported in Cancer Discovery.

People with a rare genetic coding variant that occurs in approximately 1 in 3,000 people had lower BMI and 54% lower odds for obesity compared with those who were not heterozygous carriers, data published in Science show.

NATIONAL HARBOR, Md. — Certain genetic biomarkers predicted long-term overall survival for patients who received adoptive cell therapy with tumor infiltrating lymphocytes for metastatic melanoma, according to the results of a multicenter, retrospective study presented at Society for Immunotherapy of Cancer Annual Meeting.