Weight Loss

There is no substantial evidence that losing weight before a kidney transplant improves the survival of transplant candidates with obesity, and some research suggests the opposite may be true. Yet, many patients with ESKD and obesity are getting turned away by transplant programs unless they lose weight.

Most macronutrient weight loss diets led to substantial improvements in CV risk factors and modest weight loss over months, according to a systematic review and network meta-analysis published in The BMJ.

Most macronutrient weight loss diets led to substantial improvements in CV risk factors and modest weight loss over months, according to a systematic review and network meta-analysis published in The BMJ.

Adolescents with obesity who did not respond to lifestyle therapy saw a greater reduction in BMI standard deviation score during a 1-year intervention with the GLP-1 receptor agonist liraglutide compared with similar adolescents assigned placebo, according to findings from a randomized controlled trial accepted for presentation at the Endocrine Society Annual Meeting and published in The New England Journal of Medicine.

Adults with obesity but without type 2 diabetes before undergoing bariatric surgery are 1.5 times more likely to achieve both a BMI less than 30 kg/m² and excess body weight loss of 50% or more compared with similar adults who have diabetes, according to findings accepted for presentation at the Endocrine Society Annual Meeting.

Adults with overweight or obesity and very poor baseline physical fitness lost less body weight during an 18-month behavioral weight loss intervention compared with those who had poor or better baseline physical fitness levels, according to findings accepted for presentation at the Endocrine Society Annual Meeting.

Adults who underwent duodenal mucosal resurfacing had improved glucose response and insulin sensitivity that suggest positive effects of the procedure on beta-cell function and the liver, according to data accepted for presentation at the Endocrine Society Annual Meeting and delivered in a virtual press conference.

A study published in the Journal of American College Cardiology showed that sleep irregularity was associated with an increased risk for CVD. It was the top story in cardiology last week.

Adolescents and young adults with obesity who underwent sleeve gastrectomy experienced a reduction in bone mineral density measures in the year after surgery when compared with nonsurgical controls, but did not experience a decrease in bone strength despite significant weight loss, according to findings published in Bone.

Combining liraglutide with intensive behavioral therapy at primary care sites led to more weight loss for adults with obesity than behavioral therapy alone, according to findings published in Obesity.