Washington University School Of Medicine In St Louis

Tobacco use is the leading preventable cause of cancer, responsible for nearly 30% of cancer-related deaths in the U.S. annually.

An increasing body of evidence shows that using younger, less heavily pretreated T cells results in more effective chimeric antigen receptor T-cell therapies.

Nonalcoholic fatty liver disease, or NAFLD, a condition traditionally treated by hepatologists, is widespread and frequently associated with obesity, insulin resistance, diabetes and other metabolic risk factors. Type 2 diabetes appears to worsen the course of NAFLD and promote development of nonalcoholic steatohepatitis, or NASH, the more severe form of the disease, as well as increase risks for cirrhosis and hepatocellular carcinoma. Liver disease similarly makes diabetes management more challenging. At least half of all individuals with type 2 diabetes also have NAFLD, setting the stage for a worse metabolic profile and greater cardiovascular risks. Currently, there are no drugs approved to treat NAFLD.

BARCELONA — AMG 510 appeared well-tolerated and showed promising antitumor activity among patients with locally advanced or metastatic non-small cell lung cancer, with 96% of patients achieving disease control, according to phase 1 study results presented at International Association for the Study of Lung Cancer World Conference on Lung Cancer.

The idea of “sunshine in a bottle” — vitamin D supplementation — has been promoted as a possible fix for everything from bone and immune system health to depression, dementia and diabetes, and the premise sells. It has also been investigated as a strategy for CVD prevention, but results to date have been negative.

The Leukemia Research Foundation awarded $1.2 million in research grants.

CHICAGO — At the ASCO Annual Meeting, Lindsay Peterson, MD, breast medical oncologist at the Washington University School of Medicine, spoke with HemOnc Today about the “important” findings of the Women’s Health Initiative Dietary Modification trial.

The belief that the spine moves independently of the pelvis and hip has been disproved in recent years as researchers repeatedly identified important connections between the alignment of the spinal column and the position of the pelvis. As a result, the treatment of patients with hip-spine pathology is now headed in a new direction, according to orthopedic surgeons interviewed for this Cover Story.

CHICAGO — Proton chemoradiotherapy significantly reduced incidence of adverse events associated with unplanned hospitalizations compared with traditional photon chemoradiotherapy among adults with nonmetastatic cancers, according to results of a comparative effectiveness study presented at ASCO Annual Meeting.

Click here to read the Cover Story, “Advances in chronic lymphocytic leukemia suggest progress is ‘visible on the horizon’.”