Vertebral Fracture

Romosozumab improved bone mineral density at the lumbar spine, total hip and femoral neck, and reduced the relative risk for fractures in women with osteoporosis and mild-to-moderate chronic kidney disease, according to study data.

Adults with acromegaly are more likely to experience a vertebral fracture than those without the disease, and high growth hormone levels increase fracture risk, according to study data from Italy.

Romosozumab is associated with marked reductions in all vertebral fracture grades, and these are sustained after transition to antiresorptive agents, post hoc analyses from the FRAME and ARCH studies show.

Amber Implants has announced FDA breakthrough device designation for the VCFix spinal system for treatment of vertebral fractures, according to a company press release.

Patients with rheumatoid arthritis who receive even low daily doses of glucocorticoids are at a 59% increased risk for clinical vertebral fracture, according to data published in Rheumatology.

Morphometric vertebral fractures are one of the most common comorbidities among adults hospitalized with COVID-19, and the presence of such fractures may predict the severity of disease outcomes, study data show.

Delaying denosumab doses by more than 4 months is associated with increased risks for vertebral fracture compared with on-time injections, according to findings published in Annals of Internal Medicine.

Women with postmenopausal osteoporosis who received the monoclonal antibody romosozumab were less likely to sustain a vertebral fracture during 12 months of treatment compared with women who received placebo or alendronate, study data show.

A cohort of postmenopausal Japanese women were more likely to sustain a vertebral fracture if they had thyroid-stimulating antibodies compared with women without the antibody, independent of age and severe osteoporosis status, according to findings published in Clinical Endocrinology.

Adults with pheochromocytoma or paraganglioma are nearly five times more likely to experience a vertebral fracture, a hallmark of osteoporosis, when compared with adults with nonfunctional adrenal tumors, according to findings published in Bone.