Vancomycin

LAS VEGAS — Intraosseous vancomycin infusion during total hip arthroplasty was feasible for timely delivery of periprosthetic infection prophylaxis, according to a presenter at the American Academy of Orthopaedic Surgeons Annual Meeting.

In this video, Paul Feuerstadt, MD, FACG, AGAF, spoke about new changes to the American College of Gastroenterology’s guidelines on Clostridioides difficile infection treatment, which were discussed at the ACG Annual Scientific Meeting.

Administering a beta-lactam antibiotic before vancomycin significantly reduced mortality rates among patients being treated for bloodstream infections, according to a study published in Clinical Infectious Diseases.

Intraosseous delivery of vancomycin after tourniquet inflation is safe and effective for reducing periprosthetic joint infection after primary total knee arthroplasty, according to published results.

Use of intrawound vancomycin powder during fracture fixation of tibial articular fractures may reduce the risk of gram-positive deep surgical site infections among patients at high risk for infection, according to published results.

Investigators found vancomycin preconditioning followed by SER-287 was significantly more effective compared with placebo for induction of remission in patients with active mild-to-moderate ulcerative colitis.

Revised clinical practice guidelines for Clostridioides difficile that were published in February 2018 led to immediate, significant increases in oral vancomycin and fidaxomicin use in the United States, as well as a significant decrease in oral metronidazole use, according to findings published in Clinical Infectious Diseases.

NEW ORLEANS — Results presented at the AAP National Conference & Exhibition showed use of intrawound vancomycin powder and betadine irrigation at the end of posterior spinal fusion significantly lowered the surgical site infection rate in patients with idiopathic scoliosis.

DENVER — At the Orthopaedic Trauma Association Annual Meeting, Robert V. O’Toole, MD, spoke about the effect topical vancomycin powder has on fracture surgery with regard to bacteriology and antibiotic susceptibilities. He said that use of vancomycin powder does not create more infections with pathogens that are difficult to treat compared to use without it.

An electronic medical record-driven antimicrobial stewardship program implemented in an Australian ICU was associated with high clinician compliance with recommendations and an improvement in the appropriateness of antibiotic prescriptions, researchers reported.