Vancomycin

SAN DIEGO — Prophylactic measures such as vancomycin, povidone-iodine and saline irrigation yielded similar rates of periprosthetic joint infection and wound complications at 3 months for high-risk patients undergoing joint arthroplasty.

Oral vancomycin therapy resulted in clinical response in nearly half of patients with inflammatory bowel disease associated with primary sclerosing cholangitis, according to a study published in Therapeutic Advances in Gastroenterology.

DALLAS — Results showed betadine wash, vancomycin powder and betadine wash plus vancomycin powder had no differences in wound complication, superficial infection and deep periprosthetic joint infection rates after total joint replacement.

DALLAS — Data presented at the American Association of Hip and Knee Surgeons Annual Meeting showed use of intraosseous vancomycin infusion may reduce periprosthetic joint infection vs. IV vancomycin in revision total knee arthroplasty.

Although daptomycin remains more expensive than vancomycin, it is a “suitable alternative” to daptomycin for outpatient parenteral antimicrobial therapy because it results in less health care utilization, researchers reported.

Results from this prospective quality control study showed patients who received intrawound vancomycin powder had higher rates of periprosthetic joint infection and reoperations vs. patients who did not receive intrawound vancomycin powder.

SAN FRANCISCO — In this video from the American Academy of Orthopaedic Surgeons Annual Meeting, Robert V. O’Toole, MD, FAAOS, discussed results from several trials on infection and outcomes after fracture surgery.

Drug allergy diagnosis could become more precise, cutting down on mislabeled allergies and needless drug avoidance, as a result of upcoming work comparing different types of drug hypersensitivity reactions.

LAS VEGAS — Results of the Otto Aufranc Award-winning paper showed higher concentrations of vancomycin and significantly lower systemic vancomycin levels with intraosseous vancomycin injection among patients who had total hip arthroplasty.

A large study conducted at more than 800 hospitals found that antibiotic prophylaxis guidelines were not followed in more than two-fifths of inpatient elective surgeries.