University Of Michigan Ann Arbor
Promising investigational therapy improves survival in aggressive childhood brain tumor
An international team of investigators has identified a drug candidate that nearly doubles survival rates for patients with diffuse midline glioma, an aggressive type of childhood brain tumor.
Low vitamin D levels linked to chemotherapy-induced peripheral neuropathy
Individuals with insufficient levels of vitamin D prior to treatment with paclitaxel are at higher risk for developing chemotherapy-induced peripheral neuropathy, study results showed.
Most hospitals do not systematically screen for social determinants of health in pregnancy
Fewer than half of hospitals participating in a maternity care quality collaborative reported systematic screening for social determinants of health in pregnancy, researchers reported in the American Journal of Obstetrics and Gynecology.
Cardiac rehab participation after TAVR remains poor; researchers seek answers
Fewer than one in three adults who underwent transcatheter aortic valve replacement in Michigan participated in cardiac rehab within 90 days of discharge, but hospital-level variations were not explained by patient case mix, data show.
Sotatercept expected to raise life expectancy, lower hospitalizations in PAH
Patients with pulmonary arterial hypertension receiving sotatercept, a novel activin signaling inhibitor, plus background therapy are expected to live longer, according to a European Respiratory Society International Congress presentation.
Oral nonsteroidal treatment reduces glucocorticoid dose in congenital adrenal hyperplasia
Adults with congenital adrenal hyperplasia receiving an oral corticotropin-releasing factor type 1 receptor antagonist had a greater reduction in daily glucocorticoid dose at 24 weeks than placebo, according to top-line phase 3 trial data.
Weight-based dosing strategy could sharply reduce spending on U.S. cancer drugs
Combining weight-based dosing and single-use vial sharing within individual Veterans Affairs hospitals could reduce immune checkpoint inhibitor spending by millions annually, according to study results published in Health Affairs.
Study: Vision testing rates at well-child visits low in US
Despite guidelines recommending yearly testing, the probability of receiving a vision test from a primary care physician was low in youth and varied by insurance status, a recent study found.
Patients with diabetes, worsening HF benefit from sotagliflozin at or before discharge
In a post hoc analysis of SOLOIST-WHF, patients with type 2 diabetes hospitalized for worsening HF had lower rates of CV death and HF rehospitalization if they received sotagliflozin on or before discharge than if they did not.
Little regret, high satisfaction years after gender-affirming mastectomy
Individuals who underwent gender-affirming mastectomy reported low rates of regret and high levels of satisfaction more than 2 years after surgery, according to a cross-sectional survey study published in JAMA Surgery.