University Of California Los Angeles

Women with high-risk congenital heart disease have traditionally been advised to avoid pregnancy, but that is no longer the case if the pregnancy is managed properly, according to a new American Heart Association scientific statement.

One of my mentors in residency used to say, “My worst day of private practice is better than my best day of residency.” And this is from someone who often spoke fondly of the adventures of residency training. This quote gave me hope that the future would be bright. It turns out that the practice of ophthalmology is not quite that simple, but it is true that every year is better than the previous one.

COPENHAGEN, Denmark — Neoadjuvant abemaciclib with or without anastrozole led to significantly greater reductions in tissue Ki67 after 2 weeks of treatment than anastrozole alone among postmenopausal women with hormone receptor–positive, HER-2–negative breast cancer, according to interim phase 2 study results presented at the European Society for Medical Oncology Congress.

Racial and ethnic disparities in attention-deficit/hyperactivity disorder medication persisted because of fewer diagnoses and treatments in African-American and Latino children as opposed to overdiagnoses and treatments in white children, according to study findings.

Among incretin-based drugs for managing type 2 diabetes mellitus, glucagon-like peptide 1 agonists are associated with an increased risk for bile duct and gallbladder disease, but are not associated with an increased risk for acute pancreatitis compared with other oral antidiabetic drugs, according to study results published in JAMA Internal Medicine.

BOSTON — A 14-year analysis of minimum inhibitory concentration, or MIC, data for imipenem showed that the proportion of Enterobacteriaceae isolates with low-MICs appears to be decreasing while isolates with elevated-MICs are increasing.

CHICAGO — The addition of palbociclib to letrozole significantly prolonged PFS in postmenopausal women with ER–positive, HER-2–negative advanced breast cancer who had not previously received systemic therapy for advanced disease, according to the results of the confirmatory phase 3 PALOMA-2 trial presented at the ASCO Annual Meeting.

CHICAGO — Patients who self-reported symptoms using a web application experienced earlier detection of relapse and improved survival, according to a results of a randomized phase 3 trial presented at the ASCO Annual Meeting.

Colorectal cancer has generally been classified as a sporadic disease because of a limited understanding about which patients will be diagnosed with it, but emerging evidence has identified several genetic predispositions for the disease, according to Zev Wainberg, MD, of UCLA.