University College London
ASCO studies reveal ‘unprecedented’ benefit with CAR-T as earlier treatment
Now that chimeric antigen receptor T-cell therapy has become part of the treatment landscape in hematologic malignancies, researchers are focused on developing more potent, less toxic agents that can be used in earlier treatment settings.
‘Cocaine use is extremely common’: Data suggest testing for drug prior to GPA diagnosis
Physicians should screen patients for cocaine use before making a diagnosis of granulomatosis with polyangiitis, according to data published in Rheumatology Advances in Practice.
Obe-cel CAR-T induces ‘deep, durable responses’ in B-cell ALL
CHICAGO — Seventy-six percent of adults with relapsed or refractory B-cell acute lymphoblastic leukemia achieved complete response to treatment with obecabtagene autoleucel, interim results of the pivotal phase 2 FELIX trial showed.
CRISPR-edited, donor-derived CAR-T shows early promise for T-cell acute leukemia
Two teenagers with T-cell acute lymphoblastic leukemia achieved complete molecular remission after receiving a donor-based investigational chimeric antigen receptor T-cell therapy, phase 1 study results showed.
AI models identify five distinct heart failure types, better predicting prognosis
Researchers have identified five distinct heart failure subtypes using machine learning methods across nationally representative datasets that may predict prognosis and ultimately guide treatment plans for patients.
Ambulatory vs. clinic blood pressure better predicts CV, all-cause death
Blood pressure measures obtained through ambulatory monitoring were more informative about risk for all-cause death or cardiovascular death than conventional clinic blood pressure readings, researchers reported.
Psychological interventions for depression may reduce CVD risk
Managing depression with psychological interventions may reduce CVD risk, especially in those younger than 60 years, according to a study published in the European Heart Journal.
From ‘gratitude tax’ to ‘workplace tribalism’: Combating institutional racism in academia
An “undercurrent of racism” runs throughout academic medicine, resulting in not only “disillusionment and attrition,” but also internalized racism among underrepresented groups, according to a letter published in The Lancet.
Future cytokine storm management may rely on biomarkers, predictors
SCOTTSDALE, Ariz. — Future strategies for managing cytokine storm may rely on adequately predicting treatment response, according to a speaker at the Basic and Clinical Immunology for the Busy Clinician symposium.
Rheumatologists report delaying, discontinuing advanced treatment during COVID-19 pandemic
The COVID-19 pandemic resulted in a rapid adoption of telemedicine among rheumatologists and a delaying of advanced treatments for rheumatoid arthritis, according to data published in Rheumatology Advances in Practice.